The Prefecture of Drama lies in the north-eastern part of the Region of Eastern Macedonia Thrace. Its northern borders are part of the national border with Bulgaria while to the east lies the Prefecture of Xanthi, to the south the Prefecture of Kavala
and to the west the Prefecture of Serres. In administrative terms it is part of the East Macedonia - Thrace Region and is divided into eight municipalities, those of Drama, Nevrokopi, Prosotsani, Nikiforos, Paranesti, Doxato, Kalambakio and Sitagri and one
community, Sideronero. With the river Nestos flowing through it, it is surrounded by mountains with Rhodopi to the north, Menikio and Orvilos to the west, Pangeo to the south and the Lekani mountains to the east. In terms of natural environment, ecological
interest and cultural routes it can be characterized as a truly remarkable prefecture.