Karditsa is a city in western Thessaly in mainland Greece. The city of Karditsa is the capital of Karditsa regional unit.
Inhabitation is attested from 9000 BC. Karditsa is linked with GR-30, the road to Karpenisi, and the road to Palamas and Larissa. Karditsa is south-west of Palamas and Larissa, west of Farsala and the Volos area, north-west of Athens, Lamia, Domokos and Sofades,
north of Karpenisi, north-east of Arta, and east-south-east of Trikala, Grevena, Ioannina, and Kalampaka.
Karditsa is one of the most bicycle-friendly cities in Greece with an extensive network of bicycle paths. Approximately 30% of all the city transportation, according to the National Technical University of Athens, is done by bicycles.